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Symptoms of overdose may include:
Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness ¡K
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Side Effects of This Medicine
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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Drug Interactions
It is especially important that your health care professional know if you are taking any of the following:
- Carmustine (e.g., BiCNU) or
- Cisplatin (e.g., Platinol) or
- Combination pa
in medicine containing acetaminophen and aspirin (e.g., Excedrin) or other salicylates or
- Cyclosporine (e.g., Sandimmune) or
- Deferoxamine (e.g., Desferal) (with long-term use) or
-
Gold salts (medicine for arthritis) or
- Inflammation or pain medicine, except narcotics, or
- Lithium (e.g., Lithane) or
- Methotrexate (Mexate) or
- Other medicine for infection
or
- Penicillamine (e.g., Cuprimine) or
- Plicamycin (e.g., Mithracin) or
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Precautions
Category C. Risk to fetus cannot be ruled out. Consider use if benefit outweighs the potential risk. Exposure registry is available: 1-800-722-9292, ext. 58465 (note: this number is no longer used for
antiretroviral drugs. See Health Maintenance section for the pregnancy protocols which contain the antiretroviral registry number.)
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Missing Dose
Iit is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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Description
Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.
Acyclovir is best used as soon as pos
sible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.
If you are taking acyclovir for the treatment of chickenpox , it is best to st
art taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.
Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an
empty stomach.
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