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Other medical problems
Neuroendocrine Effects:
Single doses of 30 mg or higher of buspirone resulted in significantly elevated plasma prolactin and growth hormone concentrations in normal volunteers. No effect was seen
at lower doses. In another study, no such increases were observed after buspirone was administered in divided doses (10 mg t.i.d.) for 28 days.
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What is this Drug
Buspirone (byoo-SPYE-rone) is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. However, buspirone usually is not used for anxiety or tension caused by the stress of every
day life.
It is not known exactly how buspirone works to relieve the symptoms of anxiety. Buspirone is thought to work by decreasing the amount and actions of a chemical known as serotonin in
certain parts of the brain.
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Adverse Effects
CNS:
Dizziness, headache, drowsiness, lightheadedness, insomnia, fatigue, nervousness, decreased concentration, excitement, depression, confusion, nightmares/vivid dreams, anger/hostility. Infrequ
ently (<1%) depersonalization, noise intolerance, euphoria/feeling high, dissociative reaction, fear, loss of interest, dysphoria, hallucinations, seizures, suicidal thoughts. Rarely, slurred speech,
claustrophobia, cold intolerance, stupor, psychosis.
Neurologic:
Paresthesia, weakness, incoordination, tremor, numbness. Infrequently, muscle cramps and spasms, rigid/stiff muscles, involu
ntary movements, akathisia, slowed reaction time. Rarely, tingling of limbs, stiff neck, rigidity of jaw, ataxia.
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Possible Side Effect
Although side effects from buspirone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness
- upset stomach
- vomiting
- constipation
- diarrhea
- stomach pain
- headache
- dry mouth
- depression
- excitement
- fatigue
- nervousness
- difficulty sleeping
- lighth
eadedness
- weakness
- numbness
If you experience any of the following symptoms, call your doctor immediately:
- skin rash
- itching
- fast or irregular heartbe
at
- blurred vision
- unusual movements or the head or neck muscles
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DRUG ABUSE AND DEPENDENCE :
Although preliminary animal and human investigations suggest that buspirone may be significantly devoid of potential for producing physical or psychological dependence, only extensive clinical experie
nce with the drug will provide conclusive evidence. Meanwhile, physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely, observing them for signs of b
uspirone misuse and abuse.
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Significant Interactions:
Concomitant use of MAO inhibitors and buspirone has been reported to cause an increase in blood pressure. Therefore, concomitant use of these medications is not recommended.
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