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How should you take this medication?
Take BuSpar exactly as prescribed. Do not be discouraged if you feel no immediate effect. The full benefit of this drug may not be seen for 1 to 2 weeks after you start to take it.

Symptoms of overdose may include:
In clinical pharmacology trials, buspirone up to 400 mg/day was administered to healthy male volunteers. As this dose was approached, the following symptoms were observed in descending order of freque ncy: drowsiness, ataxia, nausea and vomiting, dizziness, clammy feeling, difficulty thinking, feeling high, rushing sensation, gastric distress, headache, itching, miosis, hypotension, tremor, incoord ination, insomnia and hallucinations. In a dose ranging study in acute psychotic patients, up to 2400 mg/day was administered. Dizziness, nausea and vomiting were the most common adverse effects. One patient developed extrapyramidal symptoms at 600 mg/day.

What side effects can this medication cause?
Although side effects from buspirone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

- drowsiness
- upset stomach
- vomiting
- constipation
- diarrhea
- stomach pain
- headache
- dry mouth
- depression
- excitement
- fatigue
- nervousness
- difficulty sleeping
- lighth eadedness
- weakness
- numbness

If you experience any of the following symptoms, call your doctor immediately:

- skin rash
- itching
- fast or irregular heartbe at
- blurred vision
- unusual movements or the head or neck muscles

DRUG ABUSE AND DEPENDENCE :
Although preliminary animal and human investigations suggest that buspirone may be significantly devoid of potential for producing physical or psychological dependence, only extensive clinical experie nce with the drug will provide conclusive evidence. Meanwhile, physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely, observing them for signs of b uspirone misuse and abuse.

Description
The mechanism of action of BUSPAR is not clearly known. BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relax ant effects. It also lacks the prominent sedative effect that is associated with benzodiazepines

In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). BUSPAR has no significant affinity for benzodiazepine receptors in the brain.

Precautions
Occupational Hazards:
Until further experience is obtained with buspirone, patients should be warned not to operate an automobile or undertake activities requiring mental alertness, judgment and p hysical coordination, until they are reasonably certain that buspirone does not affect them adversely.


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