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Adverse Effects
Autonomic:
Dry mouth, sweating/clamminess, blurred vision, constipation. Infrequently, urinary frequency, retention and burning, flushing.
Cardiovascular:
Tachycardia, chest pain, palpita
tions. Infrequently, syncope, hypotension, hypertension. Rarely, congestive heart failure, cerebrovascular accident, myocardial infarction, cardiomyopathy, bradycardia, EKG change.
Gastrointestin
al:
Nausea, gastrointestinal distress, diarrhea, vomiting. Infrequently, flatulence, increased appetite, anorexia, hypersalivation, rectal bleeding, irritable colon. Rarely, burning tongue.
Re
spiratory:
Nasal congestion. Infrequently, shortness of breath, chest congestion, difficulty breathing, hyperventilation. Rarely, epistaxis.
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DRUG ABUSE AND DEPENDENCE :
Although preliminary animal and human investigations suggest that buspirone may be significantly devoid of potential for producing physical or psychological dependence, only extensive clinical experie
nce with the drug will provide conclusive evidence. Meanwhile, physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely, observing them for signs of b
uspirone misuse and abuse.
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Drug Interactions
In a study in normal volunteers, no interaction of buspirone with amitriptyline was seen. A similar study with buspirone and diazepam showed an increase in the levels of nordiazepam.
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Possible Side Effect
More common side effects may include:
- Dizziness, dry mouth, fatigue, headache, light-headedness, nausea, nervousness, unusual excitement
Less common or rare side effects may include:
- Anger/hostility, blurred vision, bone aches/pain, confusion, constipation, decreased concentration, depression, diarrhea, fast, fluttery heartbeat, incoordination, muscle pain/aches, numbness,
pain or weakness in hands or feet, rapid heartbeat, rash, restlessness, stomach and abdominal upset, sweating/clamminess, tingling or pins and needles, tremor, urinary incontinence, vomiting, weakness
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Why is this medication prescribed?
Short-term symptomatic relief of excessive anxiety in patients with generalized anxiety disorder (psychoneurotic disorder).
Eight 3-way short-term, controlled clinical trials involving buspi
rone, diazepam and placebo are considered central to the evaluation of buspirone as an anxiolytic agent. In 4 of the 8 clinical trials, buspirone demonstrated a significant difference from placebo. In
the other 4 trials, there was no significant difference between buspirone and placebo, but a significantly greater improvement was observed in 2 of these trials with diazepam than with placebo. The a
dverse effect profiles of buspirone and diazepam in these clinical trials were, however, different.
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Before Using This Medicine
Neuroendocrine Effects:
Single doses of 30 mg or higher of buspirone resulted in significantly elevated plasma prolactin and growth hormone concentrations in normal volunteers. No effect was seen
at lower doses. In another study, no such increases were observed after buspirone was administered in divided doses (10 mg t.i.d.) for 28 days.
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