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DRUG ABUSE AND DEPENDENCE :
In human and animal studies, BUSPAR has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers wi
th a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between BUSPAR and placebo. In addition, stud
ies in monkeys, mice, and rats have indicated that BUSPAR lacks potential for abuse.
Although there is no direct evidence that BUSPAR causes physical dependence or drug-seeking behavior, it i
s difficult to predict from experiments the extent to which a CNS-active drug will be misused.
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Adverse Effects
Endocrine:
Infrequently, decreased and increased libido, weight gain, weight loss, menstrual irregularity/breakthrough bleeding. Rarely, delayed ejaculation, impotence, galactorrhea, amenorrhea, t
hyroid abnormality.
Allergic or Toxic:
Skin rash, sore throat. Infrequently, edema/facial edema, pruritus, chills/fever. Rarely, photophobia, erythema, flu-like symptoms.
Clinical Laborato
ry:
Infrequently, increases in liver enzymes. Rarely, eosinophilia, leukopenia, thrombocytopenia.
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Possible food and drug interactions when taking this medication
Food increased the bioavailability of unchanged buspirone in healthy subjects, possibly due to a reduced first-pass effect.
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How should you take this medication?
Buspirone comes as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take buspirone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take buspirone even if you fe
el well. Do not stop taking buspirone without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must b
e taken regularly for a few weeks before its full effect is felt.
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Possible Side Effect
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your
doctor as soon as possible if any of the following side effects occur:
Chest pain; confusion; fast or pounding heartbeat; fever; incoordination; mental depression; muscle weakness; num
bness, tingling, pain, or weakness in hands or feet; skin rash or hives; stiffness of arms or legs; sore throat; uncontrolled movements of the body
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Symptoms of overdose
There is no specific antidote for buspirone. Management should, therefore, be symptomatic and supportive. Any patient suspected of having taken an overdose should be admitted to a hospital as soon as
possible, and the stomach emptied by gastric lavage. Respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage. As with the management of intentional overdosage wit
h any drug, the ingestion of multiple agents should be suspected. In 6 anuric patients, hemodialysis either had no effect on the pharmacokinetics of buspirone or decreased its clearance.
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