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How should this medicine be used?
The recommended initial dose is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maxim um daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.

DRUG ABUSE AND DEPENDENCE :
Although preliminary animal and human investigations suggest that buspirone may be significantly devoid of potential for producing physical or psychological dependence, only extensive clinical experie nce with the drug will provide conclusive evidence. Meanwhile, physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely, observing them for signs of b uspirone misuse and abuse.

Special Wanring
Post Introduction Clinical Experience:
Post-marketing experience in the US has shown an adverse experience profile similar to that given above. Additional reports have included rare occurrences of allergic reaction, cogwheel rigidity, dystonic reaction, ecchymosis, emotional lability and tunnel vision. Because of the uncontrolled nature of these spontaneous reports, a causal relationship to bu spirone treatment has not been determined.

Side Effects of This Medicine
Although side effects from buspirone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

- drowsiness
- upset stomach
- vomiting
- constipation
- diarrhea
- stomach pain
- headache
- dry mouth
- depression
- excitement
- fatigue
- nervousness
- difficulty sleeping
- lighth eadedness
- weakness
- numbness

If you experience any of the following symptoms, call your doctor immediately:

- skin rash
- itching
- fast or irregular heartbe at
- blurred vision
- unusual movements or the head or neck muscles

Description
BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with benzodiazepines. In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). BUSPAR has no significant a ffinity for benzodiazepine receptors in the brain.

Before Using This Medicine
The presence of other medical problems may affect the use of buspirone. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease or
- Liver disease —Buspirone may be removed from your body more slowly, which may increase the chance of side effects. Your doctor may need to adjust your dose