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DRUG ABUSE AND DEPENDENCE :
Although BuSpar does not intensify the effects of alcohol, it is best to avoid alcohol while taking this medication.

If BuSpar is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important to check with your doctor before combining BuSpar with the following:

- The blood-thinning drug Coumadin
- Haloperidol (Hal dol)
- MAO inhibitors (antidepressant drugs such as Nardil and Parnate)
- Trazodone (Desyrel)

Side Effects
More common side effects may include:
- Dizziness, dry mouth, fatigue, headache, light-headedness, nausea, nervousness, unusual excitement

Less common or rare side effects may include:
- Anger/hostility, blurred vision, bone aches/pain, confusion, constipation, decreased concentration, depression, diarrhea, fast, fluttery heartbeat, incoordination, muscle pain/aches, numbness, pain or weakness in hands or feet, rapid heartbeat, rash, restlessness, stomach and abdominal upset, sweating/clamminess, tingling or pins and needles, tremor, urinary incontinence, vomiting, weakness

Proper Use of This Medicine
Buspirone comes as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take buspirone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take buspirone even if you fe el well. Do not stop taking buspirone without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must b e taken regularly for a few weeks before its full effect is felt.

Why is this medication prescribed?
Short-term symptomatic relief of excessive anxiety in patients with generalized anxiety disorder (psychoneurotic disorder).

Eight 3-way short-term, controlled clinical trials involving buspi rone, diazepam and placebo are considered central to the evaluation of buspirone as an anxiolytic agent. In 4 of the 8 clinical trials, buspirone demonstrated a significant difference from placebo. In the other 4 trials, there was no significant difference between buspirone and placebo, but a significantly greater improvement was observed in 2 of these trials with diazepam than with placebo. The a dverse effect profiles of buspirone and diazepam in these clinical trials were, however, different.

What special precautions should I follow?
Possible Concerns Related to Buspirone's Binding to Dopamine Receptors:
Because buspirone can bind to central dopamine receptors, a question has been raised about its potential to cause acute and chronic changes in dopamine mediated neurological function (e.g., dystonia, pseudoparkinsonism, akathisia, and tardive dyskinesia). Clinical experience in controlled trials has failed to identify any significant neuroleptic-like activity; however, a syndrome of restlessness, appearing shortly after initiation of treatment, has been reported in some small fraction of buspirone treated patients. The syndrome may be explained in several ways.

Other Medicines
There is 1 report suggesting that the concomitant use of trazodone and buspirone may have caused 3- to 6-fold elevations in ALT (SGPT) in a few patients. In a similar study, attempting to replicate th is finding, no interactive effect on hepatic transaminases was identified.


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