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Symptoms of overdose may include:
Bloody or black, tarry stools; continuing thirst; dizziness; drowsiness ; headache, severe or continuing; nausea and/or vomiting; shortness of breath; stomach pain; sudden decrease in the amou nt of urine; swelling of face, fingers, and/or lower legs; tightness in chest and/or wheezing; troubled breathing; unusual tiredness or weakness; vomiting of blood or material that looks like cof fee grounds; weight gain
- lack of energy
- drowsiness
- upset stomach
- vomiting
- stomach pain

What special precautions should I follow?
Taking two or more of the nonsteroidal anti-inflammatory drugs together on a regular basis may increase the chance of unwanted effects. Also, taking acetaminophen, aspirin or other salicylates, or ket orolac (e.g., Toradol) regularly while you are taking a nonsteroidal anti-inflammatory drug may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take ever y day, and on how long you take the medicines together.However, do not take acetaminophen or aspirin or other salicylates together with this medicine for more than a few days, and do not take any keto rolac (e.g., Toradol) while you are taking this medicine, unless your doctor has directed you to do so and is following your progress.

Drug Interactions
If Celebrex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Celebrex with the following:

- ACE-inhibitors (a type of blood pressure and heart medication, including such drugs as Capoten, Vasotec, and Prinivil)
- Blood thinning agents such as Coumadin
- Fluco nazole (Diflucan)
- Furosemide (Lasix)
- Lithium (Eskalith, Lithobid)
- Thiazide diuretics (water pills) such as hydrochlorothiazide and Dyazide

If you take low-dose aspirin t o protect against heart attack, you can continue taking it with Celebrex.

What side effects may occur?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:
- Cough; fever; skin rash; sneezing; sore throat; swelling of face, fingers, feet, and/or lower legs

Why is this drug prescribed?
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis. It is the first of a new class of nonsteroidal anti-inflammatory drug s (NSAIDs) called "COX-2 inhibitors." Like older NSAIDs such as Motrin and Naprosyn, Celebrex is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unli ke the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Celebrex is therefore less likely to cau se the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.

Proper Use of This Medicine
Celecoxib comes as a capsule to take by mouth. It is usually taken once or twice a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any par t you do not understand. Take celecoxib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.


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