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Symptoms of overdose
Bloody or black, tarry stools; continuing thirst; dizziness; drowsiness ; headache, severe or continuing; nausea and/or vomiting; shortness of breath; stomach pain; sudden decrease in the amou nt of urine; swelling of face, fingers, and/or lower legs; tightness in chest and/or wheezing; troubled breathing; unusual tiredness or weakness; vomiting of blood or material that looks like cof fee grounds; weight gain
- lack of energy
- drowsiness
- upset stomach
- vomiting
- stomach pain

How should you take this medication?
Celecoxib comes as a capsule to take by mouth. It is usually taken once or twice a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any par t you do not understand. Take celecoxib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Precautions
Celecoxib may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin, other nonsteroidal anti-inflammatory drug s, or sulfonamide-type drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once. Ask someone to drive you to the nearest hospital emergency room.

What Is It
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis. It is the first of a new class of nonsteroidal anti-inflammatory drug s (NSAIDs) called "COX-2 inhibitors." Like older NSAIDs such as Motrin and Naprosyn, Celebrex is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unli ke the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Celebrex is therefore less likely to cau se the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.

What side effects may occur?
Rare side effects may include:
- heart failure, heart irregularities, hemorrhoids, hepatitis, hernia of the stomach, herpes infection, hives, hot flashes, increased appetite, increased blood pre ssure, increased heart rate, increased muscle tone, increased urination, infection, inflammation of the digestive tract, inflammation of the bladder, inflammation of the blood vessels, intestinal blee ding, intestinal obstruction or perforation, itching, jaundice, joint pain or inflammation, kidney problems, laryngitis, leg cramps, liver problems,

Possible food and drug interactions when taking this medication
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to c hange the dose, or other precautions may be necessary. When you are taking celecoxib, it is especially important that your health care professional know if you are taking any of the following:
- Aspirin or
- Fluconazole (e.g., Diflucan)—The chance of serious side effects may be increased
- Lithium (e.g., Lithane)—Higher blood levels of celecoxib and an increased chance of si effects may occur