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Significant Interactions:
It is especially important that your health care professional know if you are taking any of the following:

- Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendi n], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [ e.g., Surmontil]) or
- Central nervous system (CNS) depressants (medicines that often cause drowsiness)—These medicines may add to the effects of butalbital and increase the chance of drowsiness or other side effects
- Divalproex (e.g., Depakote) or
- Valproic acid (e.g., Depakene)—The chance of side effects may be increased

Overdose
Symptoms of Fioricet overdose can be due to its barbiturate or its acetaminophen component.

Symptoms of barbiturate poisoning may include:
- Coma, confusion, drowsiness, low blood press ure, shock, slow or troubled breathing

Overdose due to the acetaminophen component of Fioricet may cause kidney and liver damage, blood disorders, or coma due to low blood sugar. Massive dos es may cause liver failure.

Symptoms of liver damage include:
- Excess perspiration, feeling of bodily discomfort, nausea, vomiting

Other medical problems
Before taking acetaminophen, butalbital, and caffeine,

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thin ners') such as warfarin (Coumadin), antidepressants, antihistamines, pain medications, sedatives, sleeping pills, tranquilizers, and vitamins. Many nonprescription pain relievers contain acetaminophen . Too much of this drug can be harmful.

Special warnings about this medication
Check the labels of all nonprescription (over-the-counter [OTC]) or prescription medicines you now take. If any contain a barbiturate or acetaminophen, check with your health care professional. Taking them together with this medicine may cause an overdose.

Possible Side Effect
Although side effects from acetaminophen, butalbital, and caffeine are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

- drowsiness
- upset stomach
- vomiting
- stomach pain
- depression
- lightheadedness
- confusion

If you experience any of the following symptoms, call your doctor immediately:
- skin rash
- itching
- difficulty breathing

Description
Fioricet is a barbiturate sedative (butalbital) mixed with a non-aspirin pain medication (acetaminophen) and caffeine. This non-narcotic pain Fioricet and relaxant is often prescribed for tension head aches caused by contractions of the muscles in the neck and shoulder area, and migraines. . Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates th at slow down your central nervous system (brain and nerve impulses) causing relaxation. Conversely, caffeine is believed to constrict dilated blood vessels that may contribute to tension headaches. To gether, Fioricet / Acetaminophen, butalbital, and caffeine are used to relieve complex tension (muscle contraction) headaches although precisely how it works is unknown.