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Significant Interactions:
If Imitrex is taken with certain other drugs, the effects of either may be increased, decreased, or altered. It is important to check with your doctor before combining Imitrex with the following:

- Drugs classified as MAO inhibitors, including the antidepressants Nardil and Parnate
- Ergot-containing drugs such as Cafergot and Ergostat
- Fluoxetine (Prozac)
- Fluvoxamine ( Luvox)
- Paroxetine (Paxil)
- Sertraline (Zoloft)

Side Effects of This Medicine
If you develop severe chest pain, call the doctor immediately. Also seek immediate attention if you suffer sudden, severe abdominal pain after a dose of Imitrex. It could signal a blood vessel problem .

Be careful not to inject Imitrex into a vein. This can cause a serious heart irregularity.

If your fingers turn pale, then blue, after a dose of Imitrex, you may have a circulato ry problem such as hardening of the arteries. Be sure to let your doctor know.

This medication should not be used for other types of migraine headache. If the first dose does not relieve you r symptoms, your doctor will re-evaluate you; you may not have migraine or cluster headache.

Overdose
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Symptoms of Imitrex overdose may include:
- Bluish tinge to the skin, convulsions, dilated pupils, inactivity, lack of coordination, paralysis, redness in the arms and legs, skin changes at the site of injection, slow breathing, sluggishness, tremor

How should this medicine be used?
If you are not much better in 1 or 2 hours after an injection of sumatriptan, or in 2 to 4 hours after a tablet is taken, do not use any more of this medicine for the same migraine. A migraine that is not relieved by the first dose of sumatriptan probably will not be relieved by a second dose, either. Ask your doctor ahead of time about other medicine to be taken if sumatriptan does not work. Afte r taking the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment. However, even if s umatriptan does not relieve one migraine, it may still relieve the next one.

What special precautions should I follow?
Check with your doctor if you have used .Imitrex for three headaches, and have not had good relief. Also, check with your doctor if your migraine headaches are worse, or if they are occurring more oft en, than before you started using .Imitrex.

Drinking alcoholic beverages can make headaches worse or cause new headaches to occur. People who suffer from severe headaches should probably avoi d alcoholic beverages, especially during a headache.

Some people feel drowsy or dizzy during or after a migraine, or after taking .Imitrex to relieve a migraine. As long as you are feeling dr owsy or dizzy, do not drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Why is this drug prescribed?
Imitrex (Sumatriptan ) is a headache medicine. It is believed to work by causing vasoconstriction (narrowing) of arteries and veins that supply blood to your head. Imitrex ( Sumatriptan ) tablets and injections are used to treat vascular headaches such as migraine and cluster headaches. Imitrex ( Sumatriptan ) will not prevent migraines or cluster headaches or reduce the number of attacks. It will only treat a migraine or cluster headache that is already occurring. Sponsored by GlaxoSmithKline, IMITREX is the most prescribed acute migraine prescription medication in the United States


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