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is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.


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Other medical problems
Breast-feedingˇXIt is not known whether Meridia passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. A mother w ho is taking this medicine and who wishes to breast-feed should discuss this with her doctor.

Description
Patients treated with MERIDIA while on a reduced calorie diet showed significant weight loss during the first 6 months of treatment, and significant weight loss was maintained for one year. In one 12- month study, the average weight loss in patients taking MERIDIA, 10 mg daily, was about 10 lbs. and in those taking 15 mg daily was about 14 lbs. The average weight loss in persons on only a reduced c alorie diet alone was 3 1/2 lbs. Thus, MERIDIA is proven effective therapy for the obese patient who needs to loose weight to decease morbidity. Nonetheless, the magnitude of the weight loss will ulti mately depend on the degree of concomitant caloric restriction and the concomitant use of a graded exercise program.

How to Use
The recommended starting dose of MERIDIA is 10-milligrams administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks to a total of 15-mill igrams taken once daily. The 5-milligram dose should be reserved for those patients that do not tolerate the 10-milligram dose. Blood pressure and heart rate changes should betaken into consideration when making decisions regarding dose titration. Take this medication as prescribed. Do not take it more often or longer than directed. Use in combination with other appetite suppressant medicine is ge nerally not recommended.

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which
Included on your medical history/personal profile questionnaire all the medicines you use, (prescription and nonprescription), especially other weight reducing agents (e.g., diethylpropion), drugs tha t can raise blood pressure such as decongestants (e.g., pseudoephedrine, phenylpropanolamine), cough suppressants (e.g., dextromethorphan), antidepressants (e.g., nefazodone, fluoxetine, paroxetine, s ertraline, fluvoxamine, venlafaxine), lithium, psychiatric medications (e.g., MAO Inhibitors such as selegiline, moclobemide, furazolidone, phenelzine, tranylcypromine), drugs for migraines (e.g., dih ydroergotamine, sumatriptan), tryptophan, certain narcotic pain relievers, ketoconazole, erythromycin, high blood pressure medicine or any drugs which can cause drowsiness,

Cautions
Meridia may cause dizziness, drowsiness, or poor judgment. Be sure you know how you react to this medicine before you drive, operate machinery, or do other things that could be dangerous if you are no t alert and able to think clearly.

Meridia may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Howeve r, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth deca y, gum disease, and fungus infections.




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