is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.

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What side effects may occur?
If you have narrow-angle glaucoma or thyroid problems, make sure the doctor knows; Meridia should be used with caution in these circumstances. If you are prone to gallstones, be aware that weight loss can cause more of them to form. Meridia has not been tested in people under 16 years old. It should be used with caution in those over 65. Although it has been classified as a controlled substance (p otentially subject to abuse), the possibility of developing physical or psychological dependence is low.

How should this medicine be used?
The recommended starting dose of MERIDIA is 10-milligrams administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks to a total of 15-mill igrams taken once daily. The 5-milligram dose should be reserved for those patients that do not tolerate the 10-milligram dose. Blood pressure and heart rate changes should betaken into consideration when making decisions regarding dose titration. Take this medication as prescribed. Do not take it more often or longer than directed. Use in combination with other appetite suppressant medicine is ge nerally not recommended.

Why is this medication prescribed?
Meridia is used, in combination with diet and exercise, to help you lose weight. It works by decreasing your appetite.

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which
Remember that Meridia must never be taken within 2 weeks of using an MAO inhibitor such as Marplan, Nardil, or Parnate. The combination could lead to serious, even fatal, overstimulation.

Am ong the many drugs that pose a potential problem are the following:
- Fentanyl (Duragesic)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Ketoconazole (Nizoral)
- Lithium (Eska lith, Lithobid)
- Meperidine (Demerol)
- Naratriptan (Amerge)
- Paroxetine (Paxil)
- Pentazocine (Talwin NX, Talacen)
- Sertraline (Zoloft)
- Stimulants such as amphetami nes, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
- Sumatriptan (Imitrex)
- Tryptophan (L-Tryptophan)
- Venlafaxine (Effexor)
- Zolmitriptan (Zomig)

Precautions Before Using This Medicine
Pregnancy—Meridia has not been studied in pregnant women. However, studies in animals have shown that Meridia causes birth defects when used in doses many times higher than the usual human dose. Befor e taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

What special precautions should I follow?
It is important that your doctor check your progress at regular visits. Meridia may increase blood pressure or heart rate and your doctor will check for these effects. Your doctor may need to adjust y our dose.

If Meridia does not seem to be working well, do not increase your dosage. Check with your doctor.

Do not drink excess alcohol while taking Meridia.

Notify your do ctor as soon as possible if you develop a skin rash, hives, or other allergic symptoms.