is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.

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Special warnings about this medication
It is important that your doctor check your progress at regular visits. Meridia may increase blood pressure or heart rate and your doctor will check for these effects. Your doctor may need to adjust y our dose.

If Meridia does not seem to be working well, do not increase your dosage. Check with your doctor.

Do not drink excess alcohol while taking Meridia.

Notify your do ctor as soon as possible if you develop a skin rash, hives, or other allergic symptoms.

Why is this drug prescribed?
Meridia helps the seriously overweight shed pounds and keep them off. It is especially recommended for those who in addition to being overweight have other health problems such as high blood pressure, diabetes, or high cholesterol. It is used in conjunction with a low-calorie diet.

Meridia works by boosting levels of certain chemical messengers in the nervous system, including serotonin, dopamine, and norepinephrine.

Before Using This Medicine
Before taking Meridia,

- tell your doctor and pharmacist if you are allergic to Meridia or any other drugs.
- tell your doctor if you have or have ever had anorexia nervosa; glaucoma; hi gh blood pressure; arrhythmias; a stroke; gallstones; coronary artery disease; congestive heart failure; thyroid disease; seizures; or liver, kidney, or heart disease.
- tell your doctor if you a re pregnant, plan to become pregnant, or are breast-feeding.
- you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how Meridia will affect y ou.
- remember that alcohol can add to the drowsiness caused by this drug.

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which
When you are taking Meridia, it is especially important that your health care professional know if you are taking any of the following:

- Monoamine oxidase (MAO) inhibitor activity (isocarbo xazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])— Do not take Meridia while you are taking or within 2 wee ks of taking an MAO inhibitor, and do not take an MAO inhibitor within 2 weeks of taking Meridia . If you do, you may develop severe seizures, extremely high blood pressure, or the serotonin syndrome. Allow at least 2 weeks to pass between taking one of these medicines (Meridia or an MAO inhibitor) and taking the other

How should you take this medication?
The recommended starting dose of MERIDIA is 10-milligrams administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks to a total of 15-mill igrams taken once daily. The 5-milligram dose should be reserved for those patients that do not tolerate the 10-milligram dose. Blood pressure and heart rate changes should betaken into consideration when making decisions regarding dose titration. Take this medication as prescribed. Do not take it more often or longer than directed. Use in combination with other appetite suppressant medicine is ge nerally not recommended.