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is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.


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Precautions while Using this Medicine
It is important that your doctor check your progress at regular visits. Meridia may increase blood pressure or heart rate and your doctor will check for these effects. Your doctor may need to adjust y our dose.

If Meridia does not seem to be working well, do not increase your dosage. Check with your doctor.

Do not drink excess alcohol while taking Meridia.

Notify your do ctor as soon as possible if you develop a skin rash, hives, or other allergic symptoms.

What side effects may occur?
Check with your doctor as soon as possible if any of the following side effects occur:

- Achiness; chills; fast or irregular heartbeat; increased blood pressure ; mental depression; pain ful menstruation; swelling of body or of feet and ankles

- Bruising or red spots or patches on skin; convulsions (seizures); excessive bleeding following injury; headache (severe); ra pidly changing moods; skin rash; weight gain (unusual)

How should this medicine be used?
Meridia comes as a capsule to take by mouth. It is usually taken once a day and may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or ph armacist to explain any part you do not understand.

Take Meridia exactly as directed. Meridia can be habit forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to.

Before Using This Medicine
Children¡XStudies on this medicine have been done only in adult patients, and there is no specific information comparing use of Meridia in children with use in other age groups.

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which
Remember that Meridia must never be taken within 2 weeks of using an MAO inhibitor such as Marplan, Nardil, or Parnate. The combination could lead to serious, even fatal, overstimulation.

Am ong the many drugs that pose a potential problem are the following:
- Fentanyl (Duragesic)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Ketoconazole (Nizoral)
- Lithium (Eska lith, Lithobid)
- Meperidine (Demerol)
- Naratriptan (Amerge)
- Paroxetine (Paxil)
- Pentazocine (Talwin NX, Talacen)
- Sertraline (Zoloft)
- Stimulants such as amphetami nes, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
- Sumatriptan (Imitrex)
- Tryptophan (L-Tryptophan)
- Venlafaxine (Effexor)
- Zolmitriptan (Zomig)

What is this medicine
Patients treated with MERIDIA while on a reduced calorie diet showed significant weight loss during the first 6 months of treatment, and significant weight loss was maintained for one year. In one 12- month study, the average weight loss in patients taking MERIDIA, 10 mg daily, was about 10 lbs. and in those taking 15 mg daily was about 14 lbs. The average weight loss in persons on only a reduced c alorie diet alone was 3 1/2 lbs. Thus, MERIDIA is proven effective therapy for the obese patient who needs to loose weight to decease morbidity. Nonetheless, the magnitude of the weight loss will ulti mately depend on the degree of concomitant caloric restriction and the concomitant use of a graded exercise program.


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