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Drug Interactions
Pregnancy and Lactation: - Although animal studies have not shown any teratogenic or selective embryotoxic effects, the safety of paroxetine in human pregnancy has not been established. Paroxetine sho
uld not be used during pregnancy unless the potential benefit to the patient outweighs the possible risk to the fetus.
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Adverse Effects
Commonly Observed: - The most commonly observed adverse experiences associated with the use of paroxetine and not seen at an equivalent incidence among placebo treated patients were: Nausea, somnolenc
e, sweating, tremor, asthenia, dizziness, dry mouth, insomnia and male sexual dysfunction (primarily ejaculatory delay).
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Cautions
Do not take Paxil if you have taken a monoamine oxidase (MAO) inhibitor (furazolidone, phenelzine, procarbazine, selegiline, tranylcypromine) in the past 2 weeks. Do not start taking an MAO inhibitor
within 2 weeks of stopping Paxil. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, severe con
vulsions, or the serotonin syndrome.
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Before Using This Medicine
Children¡XPaxil has not be shown to be safe and effective in children or adolescents, 18 years of age or younger. Children may be especially sensitive to the effects of Paxil for the treatment of depr
ssion. This may increase the chance of a child planning to commit suicide or attempting to commit suicide. Talk to your doctor about the risks and benefits of taking this medication.
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Overdosage
No specific antidote is known. Treatment should consist of those general measures employed in the management of overdose with any antidepressant.
The stomach should be emptied either by the
induction of emesis, lavage or both. Following evacuation, 20 to 30 g of activated charcoal may be administered every 4 to 6 hours during the first 24 hours after ingestion. Supportive care with frequ
ent monitoring of vital signs and careful observation is indicated.
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What is this medicine
Paxil (pa-ROX-uh-teen) is used to treat mental depression, obsessive-compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder (also known as social phobia), premenstr
ual dysphoric disorder (PMDD), and posttraumatic stress disorder (PTSD).
Paxil belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are th
ought to work by increasing the activity of the chemical serotonin in the brain.
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