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Significant Interactions:
The presence of other medical problems may affect the use of appetite suppressants. Make sure you tell your doctor if you have any other medical problems, especially:
Alcohol abuse (or history of ) or
- Drug abuse or dependence (or history of)—Dependence on appetite suppressants may be more likely to develop
- Diabetes mellitus (sugar diabetes)—The amount of insulin or oral antidia tic medicine that you need to take may change
- Epilepsy—Diethylpropion may increase the risk of having seizures
- Family history of mental illness—Mental depression or other mental illnes may be more likely to occur

What Is It
Phentermine are used in the short-term treatment of obesity. Their appetite-reducing effect tends to decrease after a few weeks. Because of this, these medicines are useful only during the first few w eeks of a weight-loss program. The Phentermine can help you to lose weight while you are learning new ways to eat and to exercise. Changes in eating habits and activity level must be developed and con tinued long-term in order for you to continue losing weight and to keep the lost weight from returning.

How should this medicine be used?
Phentermine comes in tablets and extended-release capsules. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals. Follow the directions on your prescr iption label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Phentermine exactly as directed.

Most people take the drug for 3-6 weeks; the length of treatment depends on how you respond to the medication. Phentermine can be habit-forming.

To prevent side effects, Phentermine should be taken with meals. If you are taking an extended-rel ease (long-acting) product, do not chew or crush the tablet. There are some tablets that can be crushed and mixed with food.

What special precautions should I follow?
If you have been taking this medicine for a long time or in large doses and you think you may have become mentally or physically dependent on it, check with your doctor.

Some signs of depend ence on appetite suppressants are:
- a strong desire or need to continue taking the medicine.
- a need to increase the dose to receive the effects of the medicine.
- withdrawal side eff ects (for example, mental depression, nausea or vomiting, stomach cramps or pain, trembling, unusual tiredness or weakness) when you stop taking the medicine.

Precautions Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it may do. This is a decision you and your doctor will make. For Phentermine, the following should be c onsidered:

- Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or amphetamine, dextroamphetamine, ephedrine, epinephrine, isoproterenol, meta oterenol, methamphetamine, norepinephrine, phenylephrine, phenylpropanolamine, pseudoephedrine, terbutaline, or other appetite suppressants. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Precautions Before Using This Medicine
Before taking Phentermine,

- tell your doctor and pharmacist if you are allergic to Phentermine or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescriptio n medications you are taking, especially fluoxetine (Prozac), fluvoxamine (Luvox), guanethidine, insulin, MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)] even if you stopped taking them within the past 2 weeks, medications for weight loss and depression, paroxetine (Paxil), sertraline (Zoloft),and vitamins.
- tell your doctor if you have or have ever had heart disease, high blood pressure, arteriosclerosis (narrowing of the arteries), hyperthyroidism (overactive thyroid gland), diabetes, glaucoma, or a history of drug abuse.