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Significant Interactions:
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui
ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th
is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena
zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
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Symptoms of overdose
- unsteadiness
- confusion
- unresponsiveness
- nervousness
- tremor
- dizziness
- rapid, irregular, or pounding heartbeat
- seeing things or hearing voices tha
t do not exist (hallucinating)
- fever
- fainting
- coma
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What side effects may occur?
Check with your doctor as soon as possible if any of the following side effects occur:
- Decreased sexual drive or ability; inability to sit still; restlessness; skin rash, hives, or itchi
ng
- Chills or fever; joint or muscle pain
- Breast enlargement or pain; convulsions (seizures); fast or irregular heartbeat; purple or red spots on skin; symptoms of hypog
lycemia (low blood sugar), including anxiety or nervousness, chills, cold sweats, confusion, cool pale skin
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Possible food and drug interactions when taking this medication
Venlafaxine (e.g., Effexor)¡XUsing these medicines with fluoxetine or within 5 weeks of stopping fluoxetine may increase the chance of developing a rare, but very serious, unwanted effect known as the
serotonin syndrome. This syndrome may cause confusion, diarrhea, fever, poor coordination, restlessness, shivering, sweating, talking or acting with excitement you cannot control, trembling or shaking
, or twitching. If you develop these symptoms contact your doctor as soon as possible. Taking tramadol with fluoxetine increases the chance of having convulsions (seizures). Also, taking tryptophan wi
th fluoxetine may result in increased agitation or restlessness and intestinal or stomach problems
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Why is this drug prescribed?
In addition, Prozac is used to treat panic disorder, including panic associated with agoraphobia (a severe fear of being in crowds or public places). People with panic disorder usually suffer from pan
ic attacks--feelings of intense fear that develop suddenly, often for no reason. Various symptoms occur during the attacks, including a rapid or pounding heartbeat, chest pain, sweating, trembling, an
d shortness of breath.
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Adverse Effects
Commonly Observed: - In clinical trials, the most commonly observed adverse events associated with the use of fluoxetine and not seen at an equivalent incidence among placebo treated patients were: CN
S complaints, including headache, nervousness, insomnia, drowsiness, fatigue or asthenia, anxiety, tremor, and dizziness or lightheadedness; gastrointestinal complaints, including nausea, diarrhea, dr
y mouth and anorexia; and excessive sweating.
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