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Cautions
During the first 3 weeks you are using Retin-A, your skin may become irritated. Also, your acne may seem to get worse before it gets better. It may take longer than 12 weeks before you notice full imp rovement of your acne, even if you use the medicine every day. Check with your health care professional at any time skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks .

You should avoid washing the skin treated with Retin-A for at least 1 hour after applying it.

Avoid using any topical medicine on the same area within 1 hour before or after using Retin-A. Otherwise, Retin-A may not work properly or skin irritation might occur.

What Is It
Retin-A is used to treat acne. It works partly by keeping skin pores clear.

One of the Retin-A creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Retin-A works bes t when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by sun or the natural aging process.

Other medical problems
Older adults¡XMany medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause differ nt side effects or problems in older people. There is no specific information comparing use of Retin-A in patients 50 years of age and older with use in other age groups.

Possible food and drug interactions
Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is to be applied to the same area of the skin. When you are using topical Retin-A, it is especially important that your health care professional know if you are taking any of the following:

- Acitretin (e.g., Soriatane)
- Etretinate (e.g., Tegi son)
- Retin-A, oral ¡XMay increase chance of getting severe dryness or redness of skin

Proper Use of This Medicine
The presence of other medical problems may affect the use of Retin-A. Make sure you tell your doctor if you have any other medical problems, especially:
- Dermatitis, seborrheic or
- Eczema or
- Sunburn¡XUse of this medicine may cause or increase the irritation associated with these problems

What side effects can this medication cause?
In some animal studies, Retin-A has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other stud ies have not shown the same result and more studies need to be done. It is not known if Retin-A causes skin tumors to develop faster in humans.

Check with your doctor as soon as possible if a ny of the following side effects occur:

- Burning feeling or stinging skin (severe); lightening of skin of treated area, unexpected; peeling of skin (severe); redness of skin (severe) ; u nusual dryness of skin (severe)

- Darkening of treated skin


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