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Significant Interactions:
If Xenical is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Xenical with the fo
llowing:
- Cyclosporine (Neoral and Sandimmune)
- Warfarin (Coumadin)
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Proper Use of This Medicine
Take a capsule of Xenical during, or up to 1 hour after, each main meal. You should follow a nutritionally balanced, low-calorie diet that provides no more than 30 percent of its calories from fat. If
you miss a meal, or the meal contains no fat, you can skip the accompanying dose of Xenical.
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Why is this drug prescribed?
Xenical blocks absorption of dietary fat into the bloodstream, thereby reducing the number of calories you get from a meal. At the usual dosage level, it cuts fat absorption by almost one-third. Combi
ned with a low-calorie diet, it is used to promote weight loss and discourage the return of unwanted pounds.
The drug is prescribed for the frankly obese and for merely overweight people who
have other health problems such as high blood pressure, diabetes, or high cholesterol levels. Your weight status is determined by your body mass index (BMI), a comparison of height to weight.
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Other medical problems
Breast-feedingˇXIt is not known whether Xenical passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers w
o are taking this medicine and who wish to breast-feed should discuss this with their doctor.
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Diet Program
To help you get started on reducing the fat in your diet to about 30%, read the labels on all the foods you buy. While you are taking Xenical, you should avoid foods that have more than 30% fat. When
eating meat, poultry (chicken) or fish, eat only 2 or 3 ounces (about the size of a deck of cards). Choose lean cuts of meat and remove the skin from poultry. Fill up your meal plate with more grains,
fruits, and vegetables. Replace whole-milk products with nonfat or 1% milk and reduced- or low-fat dairy items. Cook with less fat. Use vegetable oil spray when cooking. Salad dressings; many baked i
tems; and prepackaged, processed, and fast foods are usually high in fat. Use the low- or non-fat versions of these foods and/or cut back on serving sizes.
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Side Effects
Weight loss begins within 2 weeks and continues for 6 to 12 months. The effect of using Xenical for more than 2 years is still unknown.
Side effects such as diarrhea and abdominal pain may b
e worse if you continue eating a high fat diet or even take a high-fat meal. Limit your fat intake.
Your doctor will test your thyroid function before starting you on Xenical to make sure th
at your weight problem is not due to an underactive thyroid gland (hypothyroidism). Xenical is not an appropriate remedy for this problem.
Xenical increases the likelihood of kidney stones.
Use it with caution if you have a history of this problem.
If you have diabetes, weight-loss is likely to reduce your blood sugar levels.
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