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Special Wanring
In clinical development programs, sertraline has been evaluated in 1902 subjects with depression. The most commonly observed adverse events associated with the use of sertraline were: gastrointestinal
complaints, including nausea, diarrhea/loose stools and dyspepsia; male sexual dysfunction (primarily ejaculatory delay); insomnia and somnolence; tremor; increased sweating and dry mouth; and dizzin
ess. In the fixed dose placebo controlled study, the overall incidence of side effects was dose related with a majority occurring in the patients treated with 200 mg dose.
The discontinuatio
n rate due to adverse events was 15% in 2710 subjects who received sertraline in premarketing multiple dose clinical trials.
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Possible Side Effect
Less common or rare side effects may include:
- frequent urination, hair loss, heart attack, hemorrhoids, hiccups, high blood pressure, high pressure within the eye (glaucoma), hearing problems,
hot flushes, impotence, inability to stay seated, increased appetite, increased salivation, increased sex drive, inflamed nasal passages, inflammation of the penis, intolerance to light, irregular he
artbeat, itching, joint pains, kidney failure, lack of coordination, lack of sensation, leg cramps, menstrual problems, low blood pressure, migraine, movement problems,
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Symptoms of overdose
Establish and maintain an airway, insure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be con
sidered in treating overdose.
Cardiac and vital signs monitoring are recommended along with general symptomatic and supportive measures.
There are no specific antidotes for sertral
ine.
Due to the large volume of distribution of sertraline, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.
In managing overdose,
the possibility of multiple drug involvement must be considered.
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Why is this drug prescribed?
In addition, Zoloft is used in the treatment of obsessive-compulsive disorder--symptoms of which include unwanted thoughts that won't go away and an irresistible urge to keep repeating certain actions
, such as hand-washing or counting. It is also prescribed for the treatment of panic disorder (unexpected attacks of overwhelming anxiety, accompanied by fear of their return), and for posttraumatic s
tress disorder (re-experiencing a dangerous or life-threatening event through intrusive thoughts, flashbacks, and intense psychological distress).
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Other medical problems
Older adults¡XIn studies done to date that have included elderly people, Zoloft did not cause different side effects or problems in older people than it did in younger adults. However, this medicine m
y be removed from the body more slowly in older adults. An older adult may receive a lower dose of Zoloft than a younger adult, especially when first starting treatment.
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How to Use
Zoloft is available in capsule and oral concentrate forms. To prepare Zoloft oral concentrate, use the dropper provided. Measure out the amount of concentrate prescribed by your doctor and mix it with
4 ounces of water, ginger ale, lemon/lime soda, lemonade, or orange juice. (Do not mix the concentrate with any other type of beverage.) Drink the mixture immediately; do not prepare it in advance fo
r later use. At times, a slight haze may appear after mixing, but this is normal.
Improvement with Zoloft may not be seen for several days to a few weeks. You should expect to keep taking it
for at least several months.
Zoloft may make your mouth dry. For temporary relief suck a hard candy, chew gum, or melt bits of ice in your mouth.
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