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Zovirax Ointment
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Side Effects
Parenteral:
1. Renal toxicity; precipitation of Zovirax crystals can occur in renal tubules if the maximum solubility of free Zovirax (2.5mg/ml at 37?C in water) is exceeded or if the drug is give
n by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV Zovirax manifested encephalopathic cha
nges characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; hematur
ia; hypotension; headache and nausea; thrombocytosis.
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Overdose
Zovirax is generally safe. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
Symptoms of Zovirax overdose
may include:
- Agitation, kidney failure, lethargy, coma, seizures
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How should you take this medication?
If you are using tablets, capsules, or liquid, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals.
If you are using ointment,
apply it as soon as you remember and apply further doses at your regular interval (e.g., every 3 hours) until you go to bed.
However, if it is almost time for the next dose, skip the missed
dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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How should this medicine be used?
If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to
catch up.
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Before Taking This Medicine
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Zovirax, the following should be consi
dered:
Allergies¡XTell your doctor if you have ever had any unusual or allergic reaction to Zovirax. Also tell your health care professional if you are allergic to any other substances, such
s preservatives or dyes.
Pregnancy¡XTopical Zovirax has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studie
using mice, rats, or rabbits, except when given in very high doses in a study using rats.
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Drug Interactions
If Zovirax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zovirax with the fo
llowing:
- Cyclosporine (Sandimmune, Neoral)
- Interferon (Roferon-A)
- Probenecid (Benemid)
- Zidovudine (Retrovir)
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