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Possible food and drug interactions
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Alcohol or
- Antipsychotics (medicine for mental
illness) or
- Corticosteriods(cortisone-like medicine) or
- Fluoxetine (e.g., Prozac) or
- Lithium (e.g., Lithane) or
- Maprotiline (e.g., Ludiomil) or
- Theophylline (e.g., S
omophyllin-T) or
- Trazodone (e.g., Desyrel) or
- Ritonavir (e.g., Norvir)¡XUsing these medicines with Zyban may increase the risk of seizures
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Symptoms of overdose
- difficulty breathing or swallowing
- dizziness
- fainting
- shakiness
- sweating
- confusion
- blurred vision
- seizure
- seeing things or hearing voices
that do not exist (hallucinating)
- loss of consciousness
- rapid or pounding hearbeat
- blurred vision
- lightheadedness
- confusion
- lack of energy
- upset stoma
ch
- jitteriness
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Before Using This Medicine
Pregnancy¡XStudies have not been done in pregnant women. However, Zyban has not been reported to cause birth defects or other problems in animal studies.
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Proper Use of This Medicine
Treatment with this drug begins while you are still smoking. Zyban needs about a week to reach an effective level in your body; so to improve your chance of success, you should not attempt to quit unt
il the second week of treatment. Set a firm date for quitting. If you are still smoking after that date, your odds of breaking the habit will be worse. You should keep taking Zyban for 7 to 12 weeks.
You can use nicotine patches along with Zyban. However, combining the two treatments can raise your blood pressure, so it's important to tell your doctor if you plan to use both. Do not smok
e while using a patch, because too much nicotine can cause serious side effects.
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Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your
doctor as soon as possible if any of the following side effects occur:
More common
- Agitation; anxiety
Less common
- Buzzing or ringing in ears; headache (severe); sk
in rash, hives, or itching
Rare
- Confusion; extreme distrust; fainting; false beliefs that cannot be changed by facts; hallucinations (seeing, hearing, or feeling things that are
not there); seizures (convulsions), especially with higher doses; trouble in concentrating
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What is this medicine
3 Zyban (Wellbutrin SRR, ZybanR)
Approved indication: 1) Symptomatic relief of depressive illness (effectiveness for use > 8 weeks has not been evaluated in controlled trials). 2) As an aid to smo
king cessation (6-7 weeks).
Mechanism of action: Zyban is chemically related to sympathomimetic drugs and unrelated to other antidepressants. It blocks reuptake of noradrenaline and dopamine,
but the mechanism for its clinical effects is unknown.
Pharmacokinetics: It is extensively metabolized by the liver to at least 3 active metabolites. Half-life of parent drug and active meta
bolites is 20 to 37 hrs.
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