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Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
- Agitation; anxiety

Less common
- Buzzing or ringing in ears; headache (severe); sk in rash, hives, or itching

Rare
- Confusion; extreme distrust; fainting; false beliefs that cannot be changed by facts; hallucinations (seeing, hearing, or feeling things that are not there); seizures (convulsions), especially with higher doses; trouble in concentrating

Precautions while Using this Medicine
Drinking of alcoholic beverages should be limited or avoided, if possible, while taking Zyban. This will help prevent seizures.

This medicine may cause some people to feel a false sense of we ll-being, or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerou s if you are dizzy or are not alert and clearheaded.

Overdosage
Information on Zyban overdose is limited. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Symptoms of Z yban overdose may include:
- Blurred vision, confusion, grogginess, jitteriness, light-headedness, nausea, seizure, sluggishness, visual hallucinations

Other medical problems
Zyban has not been tested in pregnant women. If you are pregnant or plan to become pregnant, do your best to quit smoking with the aid of counseling and support before turning to drug therapy. For the sake of the baby, you should avoid smoking or taking nicotine in any other form while pregnant.

Zyban appears in breast milk and could affect a nursing infant. Ask your doctor whether it wi ll be better to discontinue the medication or to stop breastfeeding.

Proper Use of This Medicine
If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose , skip the missed dose and continue your regular dosing schedule.

If you take Zyban once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not t ake a double dose to make up for a missed one.

Why is this drug prescribed?
3 Zyban (Wellbutrin SRR, ZybanR)
Approved indication: 1) Symptomatic relief of depressive illness (effectiveness for use > 8 weeks has not been evaluated in controlled trials). 2) As an aid to smo king cessation (6-7 weeks).

Mechanism of action: Zyban is chemically related to sympathomimetic drugs and unrelated to other antidepressants. It blocks reuptake of noradrenaline and dopamine, but the mechanism for its clinical effects is unknown.

Pharmacokinetics: It is extensively metabolized by the liver to at least 3 active metabolites. Half-life of parent drug and active meta bolites is 20 to 37 hrs.